The mediated acceleration contributed by changes in HbA1c level or insulin use ranged from no contribution (0.00 years (95% CI, −0.02 to 0.02 years) for insulin use at 5 years to 0.07 years (95% CI, 0.02 to 0.13 years) for HbA1c level at 1 year, suggesting that a small fraction of the acceleration of dementia diagnosis could be attributed to measured changes in HbA1c level or insulin use. The gene discussed is INS; the disease is dementia.