COMT and neoplasm: One study investigated the potential association between cognitive outcomes and single nucleotide polymorphisms (SNPs) in catechol-o-methyl transferase (COMT), brain-derived neurotrophic factor (BDNF), and dystrobrevin-binding protein 1 (DTNBP). These genes are associated with memory and daily functioning, and all genes are implicated in neurological impairment in adult tumor patients [18].