In fact, in addition to the existing evidence that natural products such as shikonin can induce necroptosis, many traditional chemotherapy or molecular targeted drugs that have recently been approved for clinical trials have been identified as cancer necrosis inducers in some cancer types [38, 39], such as VEGFR inhibitors, m-TOR inhibitors, etc. Inducing necrosis in cancer cells is not necessarily toxic to normal cells, and even leads to serious side effects in vivo. Here, KDR is linked to cancer.