TGFB1 and chondrodysplasia: The effect of losartan on osteoarthritic knee effusion has been noticed previously by Thomas et al., where losartan was able to attenuate the progression of OA in knee joints of a chondrodysplasia mouse model, reducing the degeneration of knee joint articular cartilage and halting the inflammatory process through the inhibition of TGF-β1 signaling pathway [51].