In addition, we further demonstrated inflammatory-related pathways were significant enriched including TNF, JAK-STAT, IL-17 signaling, Cytokine-cytokine receptor interaction and NF-kappa B signaling pathway, while cardiomyocyte-related pathways were down-regulated, including Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes, Calcium and Wnt signaling pathway (Figure 2D, 2E and Supplementary Table 5). The gene discussed is TNF; the disease is dilated cardiomyopathy.