The KEGG enrichment analysis revealed that these up-regulated ARGs were correlated to HIF-1 signaling pathway, ECM-receptor interaction, Focal adhesion and cancer-related pathways, but the down-regulated ARGs were enriched in Dilated cardiomyopathy and Hypertrophic cardiomyopathy (Figure 3C, 3D). The gene discussed is HIF1A; the disease is cancer.