Through variant transcript analysis, we identified massive DEGs for TAAD patients and these DEGs were significant enriched in the activation of inflammatory signaling and response to stimulus or stress, including TNF, JAK-STAT, IL-17 signalings, Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, and Fluid shear stress and atherosclerosis. Here, TNF is linked to atherosclerosis.