Infertility in women with CF is less prevalent than with their male CF counterparts with 35%-50% of women with CF reporting subfertility or infertility.1 Unlike in men, CFTR mutations in women do not alter reproductive anatomy, rather, the CFTR mutation primarily affects the function of the epithelial cells which line the reproductive tract resulting in physicochemical abnormalities. This evidence concerns the gene CFTR and Infertility.