With an increasing median age of survival (40-50 years) since the introduction of CFTR modulators, there is a progressive change in survival allowing adults with CF to consider the new prospective of parenthood.8 Cystic fibrosis patients and physicians must know the most appropriate time to discuss reproductive needs in the setting of reduced fertility/infertility and the potential role of ART. The gene discussed is CFTR; the disease is cystic fibrosis.