KLK3 and cancer: A previous study by Han et al16 evaluating the performance of mpMRI, PSAD, and a combined model including both demonstrated that the combined model shows better performance (AUC = 0.682, 0.867, and 0.896 for PSAD, mpMRI, and combined model, respectively) for cancer diagnosis in patients with PSA levels of 4-10 ng/mL.