Despite high sensitivity rates of PSA levels in the diagnosis of PC, the low specificity rates yield to unnecessary biopsy procedures.6-8 The PSA cutoff value of 4 ng/ml is considered as a common threshold for the biopsy decision.2 In the current study, the cutoff value of 4 ng/mL demonstrated high sensitivity and low specificity in the diagnosis of CSPC. Here, KLK3 is linked to pachyonychia congenita.