In a study evaluating the immune infiltration of PCa, it was reported that the diffuse lymphocyte infiltration of the tumor provided higher survival compared to lower infiltration.17 In addition, there are studies showing that high numbers of CD4 T lymphocyte invasions are associated with poor disease outcomes, such as postoperative biochemical recurrence and cancer-specific death.17,18 In a study by Rui et al,19 the T-helper-2 infiltration of immune cells was found to be associated with the recurrence of PCa. This evidence concerns the gene CD4 and cancer.