The IMAGiC model predicts response to ICI in patients with advanced gastric cancer based on the expression signature of four genes (ubiquitin C-terminal hydrolase L1 [UCHL1], tyrosine kinase 2 [TYK2], protein kinase D1 [PRKD1], and armadillo repeat-containing X-Linked 1 [ARMCX1]). The gene discussed is UCHL1; the disease is gastric cancer.