Even though HIV-1-specific T cells specific for three epitopes (HLA-A*11:01-NefQK10, HLA-A*24:02-NefRF10, and HLA-B*54:01-PolFV11) were not detected by both assays in PBMCs collected at pre-cART from two AIDS patients, these T cells were induced after these PBMCs were stimulated with epitope peptides in vitro. This evidence concerns the gene HLA-B and AIDS.