N‐acetyltransferase 10 (NAT10), as a member of the GCN5‐related N‐acetyltransferases (GNAT) family of histone acetyltransferases, is the only known RNA ac4C “writer” protein in mammals.[10] Several studies reported the involvement of NAT10 in multiple biological processes including aging and depression.[11] However, no evidence exists to show the role and mechanism of NAT10‐mediated modification of mRNA acetylation in the spinal dorsal horn in neuropathic pain. Here, NAT10 is linked to major depressive disorder.