Finally, we noted subtle differences in the extent to which Bcl2 is inhibited and Caspase 3 is activated following CK21 treatment of the two pancreatic tumor cell lines and two patient-derived organoids; these observations underscore the notion that broad inhibition of RNA transcription allows CK21 to leverage distinct vulnerabilities and pathways to achieve apoptosis in different tumor cells. Here, CASP3 is linked to neoplasm.