CASP3 and pancreatic neoplasm: Because most apoptotic pathways lead to the activation of cysteine-dependent aspartate-specific proteases, and ultimately to cleaved effector caspases such as caspases-3,–6 and –7 Redza-Dutordoir and Averill-Bates, 2016, we probed for cleaved caspase-3 in pancreatic tumors incubated with CK21.