Furthermore, in two mouse pancreatic tumor cell lines derived from genetically modified KC or KPC mice that were only modestly sensitive to CK21 treatment (Figure 4—figure supplement 4), DDIT4 as well as other early responder genes showed strong alterations in expression profiles comparable to tumors that were more sensitive to CK21 (Figure 4—figure supplement 5). This evidence concerns the gene CALCA and pancreatic neoplasm.