Immunohistochemistry and WB for CCN2, α-SMA, and collagen α1.miRNA extraction of all cell types and qRT-PCR forhsa-miR-214-3p.Transfection of all cell types with hsa-miR-214-3p/mimics/NC and qRT-PCR for miRNA and CCN2.Co-culture of transfected and untransfected cells followed by qRT-PCR for miRNA and CCN2.Serum sEV-miRNA: qRT-PCR.Endometriosis mouse model: sEV-miRNA uptake experiment, qRT-PCR. The gene discussed is CCN2; the disease is endometriosis.