Specifically inhibiting the interaction of SIN1 with RAS could be interesting because whereas it was recently shown that the SIN1‐RBD is not essential for the physiological function of mTORC2 in healthy cells,30 several authors have demonstrated that disrupting the RAS‐mTORC2 interaction impaired RAS‐dependent tumour growth in vivo.29 This evidence concerns the gene MAPKAP1 and neoplasm.