PIK3CA and cancer: Cancer is a daunting complex multifactorial disease, involving acquisition of capacities that can be summarized in the holistic tools proposed by Hanahan as the “hallmarks of cancer.”55 Dysregulation of PI3K‐AKT‐mTOR is central to several of these hallmarks such as enabling senescent cells, evading growth suppressors, sustaining proliferative signaling, deregulating cellular metabolism and resisting cell death.