LMNA and Hutchinson-Gilford progeria syndrome: The most notable example of such a breakdown occurs in the human premature aging disorder, Hutchinson-Gilford Progeria Syndrome (HGPS), which is typically caused by a germline mutation in lamin A that leads to an aberrant splice site in the gene and a protein product, termed progerin, that is missing part of the C-terminal region (De Sandre-Giovannoli et al., 2003; Eriksson et al., 2003).