APS-AuNP was found to induce maturation of DCs through phenotypic markers with functional changes, promote proliferation of T cells, increase CD4+/CD8+ T lymphocytes as well as effector memory cells, and enhance killing of 4T1 tumor cells as assessed by flow cytometry.The inhibition rate of APS-AuNP on primary tumor growth and lung metastasis of 4T1 in mice was higher than that in paclitaxel-treated group. The gene discussed is CD4; the disease is neoplasm.