Recently, Fang and colleagues demonstrated that IDO1 regulates expression of ADAM metallopeptidase domain 10 (ADAM10) via IDO1-Kyn-AhR pathway in non-small cell lung cancer (NSCLC) cells and that the induction of ADAM10 downregulates the NKG2D Ligand (NKG2DL). This evidence concerns the gene IDO1 and non-small cell lung carcinoma.