A recent RNAseq study of the TA muscle using a mouse stroke model in 5 m mice found altered transcriptomes compared to age-matched non-stroke mice including: an upregulation in stroke mice >log2fc1 of Gadd45a, Shroom3, Chrna2, and MuSK, along with downregulation (log2fc < −1) of P2ry1 [49]. This evidence concerns the gene P2RY1 and Stroke.