For instance, anti-S1 IgA has also been associated with worse clinical evolution (36, 41), suggesting that SARS-CoV-2 infection may be at least in part an IgA-mediated disease since IgA in serum can deposit on tissues, causing damage in several organs, which is a common event in severe cases of COVID-19 (42). This evidence concerns the gene PSMD1 and COVID-19.