Although the levels of Neuraminidase-1 have been correlated with ovarian cancer cell proliferation and invasion,34 an association between the ability of its enzymatic activity to regulate the sialic acid flux and the formation of spheroids, the principal mediators of ovarian cancer metastasis,35 as revealed through the global metabolic analysis of the spheroidal proteomics is as yet unknown. This evidence concerns the gene NEU1 and ovarian cancer.