On the other hand, it has also been reported that the treatment with EHF with synbiotics enhanced the management of infants with non-IgE-mediated CMPA who were already established on EHF without synbiotics, showing a significant improvement in atopic dermatitis in those patients with severe baseline symptoms (PO-SCORAD reduction from 34.7 to 18.2) (10). This evidence concerns the gene IGHE and atopic eczema.