ISG15 and bacterial infectious disease: Four Gene Ontology (GO) terms were found to be enriched in two bacterial infection response and two immune processes (Figures 5B–E): TLR4, IFNAR1, ISG15, and IL10 were associated with “response to bacterium” (GO:0009618) (Figure 5C), IFNAR1, TLR4, and IL10 were related to “response to bacterial molecule” (GO:0002237) (Figure 5D), TLR4, IL10, and ITGB2 were associated with “immune effector process” (GO:0002252) (Figure 5E).