Indeed, it is still unknown how FOXA1 alterations affect the prognosis in human cancers, and how FOXA1 is able to serve as both tumor-suppressor (Jin et al., 2013; Jin et al., 2014; Song et al., 2019) and oncogenic genes (Robinson et al., 2011; Pomerantz et al., 2015). The gene discussed is FOXA1; the disease is neoplasm.