Among them, the target genes of H3K4me3 resulting from FOXA1, GATA3 and PLOR2A as well as H3K27ac resulting from EP300 and GATA3 were significantly enriched in the gene sets (CERES = −2∼−0.4, p < 0.001), signifying a broad dependency for tumor proliferation. The gene discussed is EP300; the disease is neoplasm.