As a coactivator of the TCF/LEF family of transcription factors, it can activate Wnt response genes, such as the genes encoding cell cycle proteins like cyclin-D and c-myc that promote cell proliferation, leading to tumor fast progression in cancers such as colon, ovarian, prostate, hepatoblastoma, and hepatocellular carcinoma (O'Brien et al., 2023). Here, MYC is linked to hepatocellular carcinoma.