HNF4A and neoplasm: As a coactivator of the TCF/LEF family of transcription factors, it can activate Wnt response genes, such as the genes encoding cell cycle proteins like cyclin-D and c-myc that promote cell proliferation, leading to tumor fast progression in cancers such as colon, ovarian, prostate, hepatoblastoma, and hepatocellular carcinoma (O'Brien et al., 2023).