Research on gene mutations related to hyperthyroidism has mainly focused on individual genes, such as the study of TSHR gene mutations in congenital non-autoimmune hyperthyroidism (17–19), the impact of novel heterozygous TSHR gene mutations on hyperthyroidism (20), and special attention paid to its effects on hyperthyroidism (21). This evidence concerns the gene TSHR and hyperthyroidism.