“Hypertrophic cardiomyopathy” in the signal pathway was followed with the p.adjust value of 1.10×10-3 and the corresponding collective action gene set with mutations included 8 genes: IGF1, CACNA1S, MYH7, IL6, TTN, CACNB2, LAMA2, DMD. Here, IGF1 is linked to hypertrophic cardiomyopathy.