Based on the results presented in Figure 5, the most significant enrichment of mutated genes is in the biological signaling pathway “Thyroid hormone signaling pathway” function, followed by enrichment in the biological signaling pathway “Hypertrophic cardiomyopathy”, “Dilated cardiomyopathy”, “Neuroactive ligand-receptor interaction”, “Thyroid hormone synthesis” and “cAMP signaling pathway”. The gene discussed is TG; the disease is hypertrophic cardiomyopathy.