Rescue assays further demonstrated that FOXA3 overexpression reversed the HOXC10-silencing induced suppression on the proliferative capacity, migration, invasiveness and apoptosis of ESCC cells, which indicated that HOXC10 regulated ESCC cell malignancy at least partially through regulating FOXA3 expression. This evidence concerns the gene FOXA3 and esophageal squamous cell carcinoma.