As revealed by Co-IP assays, HOXC10 was found significantly enriched in the precipitates of anti-FOXA3 and FOXA3 was detected in the precipitates of anti-HOXC10 in ESCC cells, which indicated that HOXC10 interacts with FOXA3 in ESCC cells (Fig. 4H). This evidence concerns the gene HOXC10 and esophageal squamous cell carcinoma.