Such as, B cell populations of the respiratory mucosa can defense respiratory virus infections by secreting protective mucosal antiviral IgA [22]; lung-resident memory B cells (BRM cells) not only can provide to antibacterial immunity by secretion of heterotypic antipneumococcal IgG, but also can contribute to improving vaccine effectiveness [23,24]; lung-resident regulatory B (Breg) cells can alleviate excessive lung inflammation by suppressing pro-inflammatory cytokines over-production via producing IL-10 during pathogens infections [24,25]. This evidence concerns the gene IL10 and infection.