Finally, for the JACK-STAT (Janus kinases signal transducer) signalling pathway, KEGG analysis showed that pro-epidermal growth factor and cytokine receptors were significantly upregulated in the FD group, while the suppressor of cytokine signalling 7 and serine threonine protein kinase were downregulated (electronic supplementary material, figure S4b). The gene discussed is EGF; the disease is Fabry disease.