PLAUR and asthma: However, prior to effectively targeting uPAR, a greater understanding of (i) the potential differential expression of uPAR isoforms in asthma patient cells, (ii) the role of uPAR in epithelial cell homeostasis including barrier properties, (iii) the potential to target selected uPAR functions and (iv) the molecular mechanisms underlying the differential effects of uPAR isoforms on epithelial cell functions, is warranted.