CD79A and shigellosis: More specifically, this new shigellosis model will allow us to take a fresh look at the role of mucosal IgA in preventing Shigella dissemination36,37 and at Shigella capacity to subvert immune cell function and antimicrobial activity, which has been described previously in vitro or in vivo in other models (macrophage and B-lymphocyte apoptosis induction38,39 or T-cell migration.40,41 Most of these subversion mechanisms are dependent on Shigella Type Three Secretion System (T33S).