It has been previously shown that infection by enteropathogenic E. coli dysregulates the expression of L-ascorbic acid transporter SVCT1 and SVCT2.43 Low amount of ascorbate may impair the protective properties of epithelium barrier and tissue repair, while more global effects are anticipated on the oxidative stress level and the immune system function, since ascorbate is very important for the activity of both innate and adaptive immune cells. The gene discussed is SLC23A2; the disease is infection.