Ascorbate also sustains the differentiation and maturation of both B- and T-lymphocytes, particularly NK cells.45 It was recently shown that ascorbate boost the immunogenic properties of dendritic cells, through the NF-κB-dependent increase of TNFβ production.46 Further investigations will be required to evaluate the impact of ascorbate deficiency on the function of immune cells during shigellosis. The gene discussed is NFKB1; the disease is shigellosis.