In particular, autophagy insufficiency was observed in the kidney biopsy of patients with diabetic nephropathy and the animal models of insulin resistance with renal accumulation of p62/SQSTM1 and decreased levels of lysosome-associated membrane protein type 2A (LAMP-2A), which was accompanied by dysregulated autophagy function, enhanced lysosome dysfunction, and apoptosis [267]. This evidence concerns the gene SQSTM1 and diabetic kidney disease.