The skeletal muscle of T2DM patients with hyperinsulinemia exhibited a reduction in autophagy, which was demonstrated by the reduced expression of SQSTM1/p62, ATG14, GABARAPL1, RB1 inducible coiled-coil 1 (RB1CC1)/ family-interacting protein of 200 kDa (FIP200), and WD repeat domain phosphoinositide-interacting protein 1 (WIPI1)genes, decreased levels of SQSTM1/p62, LC3BII, and ATG5 proteins, as well as the elevated phosphorylation of FOXO3a [188]. This evidence concerns the gene WIPI1 and type 2 diabetes mellitus.