NFKB1 and cancer: According to the results of the combination of gemcitabine and 6-shogaol, 6-shogaol not only increased the sensitivity of pancreatic cancer cells PANC-1 and BxPC-3 to gemcitabine, but also enhanced the anti-cancer effect of gemcitabine by inhibiting TLR4/NF-kB signaling.