After adjusting for age (continuous), gender, race, education, smoking status, alcohol consumption, Obesity, systolic blood pressure, anti-diabetic drugs, HDL cholesterol, albumin, fasting plasma glucose, and eGFR, the association was still solid (OR = 2.02 1-SD, 95% CI 1.67–2.45, P < 0.0001). This evidence concerns the gene ALB and obesity due to melanocortin 4 receptor deficiency.