Chymase, which is a chymostatin-sensitive ANG II-generating enzyme, produces ANG II independently of ACE, and Roszkowska-Chojecka et al. [34] confirmed that chymase contributed to ANG II-dependent hypertension in adult SHRs, thus suggesting that combined blockade of ACE and chymase-like enzymes could lower blood pressure more effectively than ACE inhibition alone. The gene discussed is CMA1; the disease is hypertensive disorder.