Moreover, Shi et al. [21] demonstrated that exogenous administration of an H2S donor markedly ameliorated left ventricular remodeling and cardiac fibrosis in SHR, indicating that H2S-releasing ACEI ZOFE could be effective in the treatment of cardiovascular alterations associated with essential hypertension; however, the impact of ACE2 remains unknown. Here, ACE2 is linked to hypertensive disorder.