NRF1-TFAM axis regulates mitochondrial biogenesis and protects against mitochondrial dysfunction in alcoholic steatohepatitis.[4] NRF1 expression and NRF1-mediated mitochondrial biogenesis in liver cells are both upregulated in acute inflammation to meet the energy demand.[5] However, little is known about its function in HCC. This evidence concerns the gene NRF1 and alcoholic fatty liver disease.