Although we provide evidence that NRF1 promotes HCC progression through LPCAT1-ERK1/2-CREB axis, we could not rule out the possibility that NRF1 may inhibit HCC progression through some specific mechanisms under some specific conditions and it’s our opinion that the overall effect of NRF1 on HCC is promotive. This evidence concerns the gene CREB1 and hepatocellular carcinoma.