Second, NRF1 induces mitochondrial biogenesis and mitochondria could affect tumorigenesis in a complex and profound manner as critical cellular processes are related to mitochondria, such as oxidative phosphorylation, ATP production, ROS generation and apoptosis.[40] Our present study highlights NRF1 facilitates HCC progression by inducing LPCAT1 transcription, but whether NRF1-mediated mitochondrial biogenesis plays a role in HCC deserves further exploration. This evidence concerns the gene NRF1 and hepatocellular carcinoma.