In search of the most significant genes that mediate the oncogenic effect of NRF1, we used Venn analysis to find the intersection of the top 3000 putative NRF1 target genes (Additional file 12: Table S4), the top 500 most differential survival genes in HCC (Additional file 13: Table S5) and phospholipid biosynthetic process gene set (Additional file 14: Table S6) (Fig. 4C). The gene discussed is NRF1; the disease is hepatocellular carcinoma.