We did not analyze lipidomic change by mass spectrometry upon silencing NRF1 in our investigation, but considering the unequivocal regulation of NRF1 on LPCAT1 transcription and the explicit effect of LPCAT1 on PC metabolism,[16, 30, 31] we believe NRF1 could alter phospholipid metabolism in HCC. Here, NRF1 is linked to hepatocellular carcinoma.