LPCAT4 and hepatocellular carcinoma: LPCAT family contains four members (LPCAT1-LPCAT4) and they have different tissue distributions, enzymatic activities, and substrate preferences.[14] Among them, LPCAT1 prefers 16:0-CoA (palmitoyl-CoA) as its substrate and its main catalytic product is dipalmitoyl phosphatidylcholine (DPPC) which facilitate signal transduction from membrane to cytosol.[15] LPCAT1 was reported to promote HCC progression,[16] but how it’s upregulated in HCC remains unclear.