NFKB1 and hepatocellular carcinoma: Overexpression of LPCAT1 increase DPPC and thus upregulate the plasma membrane PC saturation which facilitate signal transduction from membrane to cytosol.[15] As continuous signaling transduction like PI3K/Akt pathway, NF-κB pathway, and MAPK pathway are fundamental drivers of HCC tumorigenesis,[15] it’s well-reasoned that LPCAT1 promotes the malignant transformation of HCC.