NRF1-TFAM axis regulates mitochondrial biogenesis and protects against mitochondrial dysfunction in alcoholic steatohepatitis.[4] NRF1 expression and NRF1-mediated mitochondrial biogenesis in liver cells are both upregulated in acute inflammation to meet the energy demand.[5] However, little is known about its function in HCC. The gene discussed is NRF1; the disease is hepatocellular carcinoma.