VWF and COVID-19: Markers of endothelial activation in the circulation were reported to be increased in COVID-19 patients and to correlate with disease severity such as soluble cell adhesion molecules including VCAM-1 [29], P-selectin [31, 76] and E-selectin [34], as well as vWF and angiopoetin-2 [31, 77] and this could be due to systemic inflammation.