The lack of ACE2 in and no SARS-CoV-2 infection of EECM-BMECs is in accordance with several other in vitro studies, which recently reported absence of productive infection of primary endothelial cells isolated from various vascular beds including the lung and the brain, iPSC-derived endothelial cells and the immortalized BMEC line hCMEC/D3, except when ACE2 over-expression was introduced by lentiviral transduction [72, 80, 83, 86, 87]. The gene discussed is ACE2; the disease is infection.