This is in agreement with previous in vitro reports, which found productive infection with SARS-CoV-2 of hPSC-derived ChP organoids [15, 99], and hiPSC-derived ChP epithelial cell aggregates [16], as well as by the fact that ChP epithelia express ACE2 and TMPRSS2 in situ [68–71]. This evidence concerns the gene ACE2 and infection.