Reports of increased levels of markers of endothelial activation and injury in the circulation of COVID-19 patients including von Willebrand factor (vWF), vascular cell adhesion molecule 1 (VCAM-1), E-Selectin, glycocalyx degradation products and circulating endothelial cells [29–34], as well as high incidence of thrombotic manifestations in multiple organs of COVID-19 patients [35] raised the question of whether endothelial cells are susceptible to SARS-CoV-2 infection. The gene discussed is VWF; the disease is COVID-19.