ACE2 and early-onset autosomal dominant Alzheimer disease: This is in line with recent single nucleus RNA sequencing data obtained from microvessels isolated from fresh-frozen post-mortem hippocampus and frontal cortex from individuals without cognitive impairment and Alzheimer’s disease patients, in which ACE2 transcripts were not detected in arterial, capillary and venous brain endothelial cells, but in a small percentage of pericytes and vascular smooth muscle cells [74].