A total of 77 SNPs were identified as IVs for MetS, 475 were for BMI, 344 were for WAC, 308 were for HDL, 267 were for TC, 38 were for T1D, 113 were for T2D, 60 were for GLU, 37 were for INS, 426 were for SBP and 430 were for DBP (Additional file 2:Table S1-S11). The gene discussed is INS; the disease is metabolic syndrome.