The IVs associated with 10 predominant ingredients for MetS were identified, including body mass index (BMI), waist circumference (WAC), serum triglycerides (TC), high-density lipoprotein (HDL) cholesterol, fasting serum insulin (INS), fasting serum glucose (GLU), type 1 and type 2 diabetes (T1D and T2D), diastolic blood pressure (DBP), and systolic blood pressure (SBP). This evidence concerns the gene INS and metabolic syndrome.