The synergistic effect of H2O2 self-supplying CDT and CBIT demonstrated by the dAbPD−L1/CD24-mPDA@CuO2 NRs in the acidic tumor microenvironment presents a promising drug-free synergistic therapy approach for breast cancer, particularly for the treatment of triple-negative breast cancer (TNBC). This evidence concerns the gene CD24 and triple-negative breast carcinoma.