Regarding the role of antipsychotics in bone remodeling or loss, some studies recently attributed this relation to alteration of regulatory cytokines with changes in serum levels of TNF-, INF-, IL-6, IL-10, IL-17, IL-27, and TGF- in schizophrenic patients with resultant reductions in BMD and eventually osteoporosis [93–96]. This evidence concerns the gene IL27 and osteoporosis.