Nevertheless, one confusing finding in the present study is that the majority of the prolactin-inducing antipsychotics group were females above 50 years of age, which infers some doubt in the assumption that the prevalence of osteoporosis among members of this group is attributed to hyperprolactinemia due to the well-established relation between structural bone changes and estrogen deficiency, especially in postmenopausal women [97–99]. Here, PRL is linked to osteoporosis.