We immunohistochemically stained for RMI2 expression in tissue samples from 60 cases of HCC and determined the resulting correlations with a variety of clinicopathological factors: patient age and gender, status of hepatitis virus infection, histological findings, tumor size, liver function, OS and DFS, and the IHC staining data of β-catenin. Here, RMI2 is linked to hepatocellular carcinoma.