In GALACTIC-HF, the median cTnI level was higher by 4 and 2 ng/L in the OM group compared to the placebo group, at weeks 24 and 48, respectively [63••]. The incidences of myocardial ischaemia, ventricular arrhythmias, and death were similar in both groups with almost 7500 patient-years of follow-up. This evidence concerns the gene TNNI3 and hydrops fetalis.