TNNI3 and infarction: Possible cardiac ischaemia or infarction were adjudicated by the study’s clinical events committee if investigators reported events suggestive of myocardial ischaemia or if cTnI concentration was > 99th percentile URL of 0·04 ng/mL when the previous concentration had been undetectable, or if the value had increased by > 0·03 ng/mL.