Interestingly, except in the PC3c cell line, which differs from PC3 in its strong osteomimicry properties, FSCN1 turned out to be highly expressed in cell lines that are negative for AR expression (Fig. 1a, b), such as PC3, PC3M and DU145, but not in any of the androgen-dependent cell lines such as LNCaP, MDA-PCa-2b and VCaP, suggesting that AR plays a role in the regulation of FSCN1 expression in PCa cells. The gene discussed is AR; the disease is posterior cortical atrophy.