IL21 and lupus nephritis: In the MRL/lpr of lupus nephritis model mice, 8-week-old mice were given IGU 30 mg/kg to intervene, and the disease activity markers (anti-dsDNA antibodies and immunoglobulins) in the serum of experimental mice after 21 weeks decreased, improved hypocomplementemia and decreased expression of cytokines such as IL-6, IL-17A and IL-21, and unconspicuous toxic and side effects of IGU were observed, indicating that 30 mg/kg has a good effect on lupus nephritis mouse model24.