Approximately one-third of human PC metastases show chromosomal loss of 6q24–25.2, which encodes the AKAP12 locus [14], and additionally, a significant number of PC metastases exhibit the transcriptional downregulation of AKAP12 [10] due to promoter hypermethylation [15]. The gene discussed is AKAP12; the disease is pachyonychia congenita.