By detecting changes in the expression levels of key regulatory factors in the metabolic pathway, we speculated that the regulatory factors CPT1, TGF-β1, Glu, and LD cytokines could promote fatty acid oxidation, inhibit glycolysis, and promote oxidative phosphorylation metabolism through the glycerophospholipid metabolic pathway of glycerophospholipids, and then regulate and affect metabolism microenvironment in patients with hyperuricemia after reprogramming. The gene discussed is TGFB1; the disease is hyperuricemia.