ONECUT3 and cancer: Since our results showed that the prostanoid metabolic process enriched in ONECUT3high PDAC is associated with high mRNAsi scores and NK cell-targeted inhibitory immune checkpoints and that ONECUT3 potentially regulates prostanoid metabolism-related genes, it is reasonable to infer that ONECUT3-mediated prostanoid metabolism may orchestrate cancer stemness and immune evasion.