In the context of osteoporosis and bone repair, siRNA targeting Runt-related transcription factor 2 (Runx2)/Core-binding factor alpha-1 (Cbfa1) has shown promise in inhibiting heterotopic ossification induced by bone morphogenetic protein 4 (BMP4), demineralized bone matrix, and trauma in animal models21. Here, BMP4 is linked to osteoporosis.