CD4 and HIV-1 infection: Recently, Mandizvo et al.17 demonstrated differences in neutralization breath of different bnAbs; 2G12 (23%) compared to 10-1074 (80%) among V3 binding bnAbs, as well as 3BNC117 (59%) compared to VRC07-LS (100%) among CD4 binding bnAbs in single env genomes from nine South African individuals followed longitudinally post-acute HIV-1 infection.