To further confirm the mechanism of Sohlh2 in the regulation of AECII oxidative stress during the development of pulmonary fibrosis, we examined the effect of Sohlh2 on regulating the p62/Keap1/Nrf2 signaling pathway in the lung tissues of 8 M and HFD-fed mice. This evidence concerns the gene SQSTM1 and pulmonary fibrosis.