In fact, there are several examples of a lack of correlation between amplification and overexpression.18 Some studies have demonstrated that CDK4 was overexpressed in sarcomas and that this overexpression entailed a worse prognosis, and when it was downregulated, proliferation was inhibited.19 However, to date, no conclusive data have been derived from the plethora of potential predictive biomarkers of CDK4 inhibitory studies. Here, CDK4 is linked to sarcoma.