While CDKN2A deep deletions were found in 8% of leiomyosarcomas (LMS), 20% of undifferentiated pleomorphic sarcomas (UPS) and 18% of myxofibrosarcomas.14 These findings constituted the basis of the exploration of palbociclib and abemaciclib, CDK4 inhibitors, in DD-LPS.15,16 Nonetheless, the proportion of STS patients with CDK4 amplification is lower than 5% apart from DD-LPS.17 The lack of a benign counterpart in the majority of sarcoma subtypes makes it more challenging to determine what might be considered categorically the threshold of mRNA overexpression. Here, CDK4 is linked to undifferentiated pleomorphic sarcoma.