IL15 and neoplasm: To develop highly efficient membrane-bound IL-15 anchored DC vesicles with tumor antigen presentation ability (biNV-IL-15), bone marrow-derived DCs (BMDC) were transduced with a combination of mouse IL-15 and IL-15Rα encoded recombinant adenovirus (IL-15/IL-15Rα rAD) and then were pulsed with the endogenous HCP (DC-IL-15/HCP) (Fig. 2a).